The lysosomotropic agent, hydroxychloroquine, delivered in a biodegradable nanoparticle system, overcomes drug resistance of B-chronic lymphocytic leukemia cells in vitro.
2/1/2010 Cancer Biother Radiopharm. 2010 Feb;25(1):97-103 Mansilla E, Marin GH, Nuñez L, Drago H, Sturla F, Mertz C, Rivera L, Ichim T, Riordan N, Raimondi C. Nonviral delivery systems are relatively easy to produce in the large scale, are safe, and elicit a negligible immune response. Nanoparticles (NPs) offer promise as nonviral vectors as biocompatible…
