Scalable efficient expansion of mesenchymal stem cells in xeno free media using commercially available reagents.
7/1/2015 J Transl Med. 2015 Jul 17;13:232 Riordan NH, Madrigal M, Reneau J, de Cupeiro K, Jiménez N, Ruiz S, Sanchez N, Ichim TE, Silva F, Patel AN. Background: The rapid clinical translation of mesenchymal stem cells (MSC) has resulted in the development of cell-based strategies for multiple indications. Unfortunately one major barrier to widespread…
Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis.
4/1/2009 J Transl Med. 2009 Apr 24;7:29 Riordan NH, Ichim TE, Min WP, Wang H, Solano F, Lara F, Alfaro M, Rodriguez JP, Harman RJ, Patel AN, Murphy MP, Lee RR, Minev B. The stromal vascular fraction (SVF) of adipose tissue is known to contain mesenchymal stem cells (MSC), T regulatory cells, endothelial precursor cells,…
Feasibility investigation of allogeneic endometrial regenerative cells.
2/1/2009 J Transl Med. 2009 Feb 20;7:15. Zhong Z, Patel AN, Ichim TE, Riordan NH, Wang H, Min WP, Woods EJ, Reid M, Mansilla E, Marin GH, Drago H, Murphy MP, Minev B. Endometrial Regenerative Cells (ERC) are a population of mesenchymal-like stem cells having pluripotent differentiation activity and ability to induce neoangiogenesis. In vitro…
Allogeneic endometrial regenerative cells: an “Off the shelf solution” for critical limb ischemia?
8/1/2008 J Transl Med. 2008 Aug 19;6:45 Murphy MP, Wang H, Patel AN, Kambhampati S, Angle N, Chan K, Marleau AM, Pyszniak A, Carrier E, Ichim TE, Riordan NH. Critical limb ischemia (CLI) is an advanced form of peripheral artery disease which is responsible for approximately 100,000 amputations per year in the US. Trials to…
Endometrial regenerative cells: a novel stem cell population.
11/1/2007 J Transl Med. 2007 Nov 15;5:57 Meng X, Ichim TE, Zhong J, Rogers A, Yin Z, Jackson J, Wang H, Ge W, Bogin V, Chan KW, Thébaud B, Riordan NH. Angiogenesis is a critical component of the proliferative endometrial phase of the menstrual cycle. Thus, we hypothesized that a stem cell-like population exist and…
Stem cell therapy for autism.
6/1/2007 J Transl Med. 2007 Jun 27;5:30 Ichim TE, Solano F, Glenn E, Morales F, Smith L, Zabrecky G, Riordan NH. Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions whose incidence is reaching epidemic proportions, afflicting approximately 1 in 166 children. Autistic disorder, or autism is the most common form of ASD. Although…
Cord blood in regenerative medicine: do we need immune suppression?
1/1/2007 J Transl Med. 2007 Jan 30;5:8 Riordan NH, Chan K, Marleau AM, Ichim TE. Cord blood is currently used as an alternative to bone marrow as a source of stem cells for hematopoietic reconstitution after ablation. It is also under intense preclinical investigation for a variety of indications ranging from stroke, to limb ischemia,…